Integrated Physiological Interaction Modeling and Simulation for Aerobic Circulation with Beat-by-Beat Hemodynamics

This chapter describes a simulation system for modeling and testing aerobic circulatory physiology on the virtual environment. There have been many models of the biological system at various scales and from various viewpoints, intended to simulate physiological changes and pathological conditions (McLeod, 1966). However, these models are designed primarily for medical education, and are unsuitable as practical tools for clinical diagnosis. The reason for this unsuitability is their insufficiently accurate quantitative representation of the physiological system compared to clinical data or the results of animal experiments (Ackerman, 1991). A further problem in developing practically useful models of biological systems is the need for expert physiologists to engage in computer programming in order to create the mathematical models. The useful modeling and simulation tool for an integrated circulatory system is important for physiological diagnosis and evaluation.